Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4

Two new compounds, triacremoniate (1) and dietziamide C (2) along with known compounds β-Adenosine (3) and acrepyrone A (4) were obtained from the mangrove-derived fungus Acremonium citrinum. MMF4. Their structures were unambiguously determined by extensive spectroscopic methods, including UV, IR, H...

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Bibliographic Details
Published in:Fitoterapia 2020-11, Vol.147, p.104766, Article 104766
Main Authors: Wang, Xiao-Yao, Ye, Xian-Sheng, Gao, Shuo, Liu, Jin-Xi, Tian, Wen-Jing, Wang, Guang-Hui, Chen, Hai-Feng, Lin, Ting
Format: Article
Language:English
Subjects:
Acremonium
Acremonium citrinum
Adenosine
Apoptosis
Cytotoxicity
Fungi
HeLa
JNK
NMR
Nuclear magnetic resonance
P38
PARP
Phosphorylation
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Summary:Two new compounds, triacremoniate (1) and dietziamide C (2) along with known compounds β-Adenosine (3) and acrepyrone A (4) were obtained from the mangrove-derived fungus Acremonium citrinum. MMF4. Their structures were unambiguously determined by extensive spectroscopic methods, including UV, IR, HRESIMS and NMR. Triacremoniate (1) can promote apoptosis of HeLa cells by increasing the PARP cleavage and the phosphorylation of JNK and p38. [Display omitted] •Two new compounds were obtained from the mangrove-derived fungus Acremonium citrinum.•Compound 1 showed obvious cytotoxicity against Hela cell line.•Compound 1 distinctly induced the apoptosis of Hela cell line.•Compound 1 significantly increased the expression of p-JNK and p-p38 in MAPK signaling pathway.
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2020.104766