Synthesis, structure, and in vitro evaluation of biological activity of CuII furancarboxylates against the non-pathogenic M. smegmatis strain

The reaction of copper( ii ) acetate with 2-furancarboxylate (Hfur, pyromucate) anions and the N-donor ligands 4-phenylpyridine (phpy) and 3-aminopyridine (NH 2 py) in acetonitrile afforded the mononuclear complexes of the composition [Cu(fur) 2 (phpy) 2 (H 2 O)] · phpy ( 1 ) and [Cu(fur) 2 (NH 2 py...

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Bibliographic Details
Published in:Russian chemical bulletin 2021, Vol.70 (3), p.463-468
Main Authors: Lutsenko, I. A., Kiskin, M. A., Koshenskova, K. A., Primakov, P. V., Khoroshilov, A. V., Bekker, O. B., Eremenko, I. L.
Format: Article
Language:English
Subjects:
Acetonitrile
Biological activity
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copper
Copper compounds
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Inorganic Chemistry
Organic Chemistry
Thermal analysis
Thermal stability
Thermodynamic properties
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Summary:The reaction of copper( ii ) acetate with 2-furancarboxylate (Hfur, pyromucate) anions and the N-donor ligands 4-phenylpyridine (phpy) and 3-aminopyridine (NH 2 py) in acetonitrile afforded the mononuclear complexes of the composition [Cu(fur) 2 (phpy) 2 (H 2 O)] · phpy ( 1 ) and [Cu(fur) 2 (NH 2 py) 2 ] ( 2 ), respectively. The structures of the complexes were established by X-ray diffraction. The simultaneous thermal analysis of the thermal behavior of complex 1 showed that this complex is thermally stable up to 125 °C. The in vitro biological activity of complexes 1 and 2 was evaluated against the non-pathogenic mycobacterial Mycolicibacterium smegmatis strain.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3109-3