Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives

A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphen...

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Bibliographic Details
Published in:Russian chemical bulletin 2021-03, Vol.70 (3), p.580-584
Main Authors: Polkam, N., Malthum, S., Anireddy, J. S., Brahma, U., Naidu Vegi, G. M.
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
Oxadiazoles
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Summary:A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphenyl)-5-propylthio-1,3,4-oxadiazole. 2-(2,5-Dimethoxyphenyl)-5-butylthio-1,3,4-oxadiazole displayed excellent activity against breast cancer cell lines.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3128-0