Phenolic lipids as unique bioactive compounds: a comprehensive review on their multifunctional activity toward the prevention of Alzheimer's disease

Phenolic lipids are multifunctional compounds which play an important biological role in the body. Their unique biologic functionality stems from their strong amphiphilic character which allows them to be incorporated in erythrocytes. Through membrane incorporation, these compounds exert their biolo...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2021, Vol.61 (8), p.1394-1403
Main Authors: Meshginfar, Nasim, Tavakoli, Hamed, Dornan, Kelly, Hosseinian, Farah
Format: Article
Language:English
Subjects:
Acetylcholinstrease
Alzheimer Disease - drug therapy
Alzheimer Disease - prevention & control
Alzheimer's disease
bilayer lipid modulation
Bioactive compounds
Biological activity
Biological effects
Diet
Erythrocytes
Humans
Leptin delivery
Lipids
Metabolites
Neurodegenerative diseases
Pathogenesis
Phenolic compounds
Phenolic lipid
Phenols
Phenols - pharmacology
Plants
resorcinols
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Summary:Phenolic lipids are multifunctional compounds which play an important biological role in the body. Their unique biologic functionality stems from their strong amphiphilic character which allows them to be incorporated in erythrocytes. Through membrane incorporation, these compounds exert their biological effects on neurons which are not modulated by hydrophilic compounds. These bioactive compounds are present in nature as secondary plant metabolites, and consequently their availability is limited, for dietary and medical purposes. In this review, the pathways and mechanisms associated with the pathogenesis of Alzheimer's disease will be described. In addition, the modulatory effects of phenolic lipids on these pathways and a list of several synthetic, semi synthetic and natural sources of phenolic lipids will be examined as having the potential to prevent or combat Alzheimer's disease.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2020.1759024