Preliminary study of uptake estimation of 99mTc-HMPAO in brain scan using gamma camera

• Published in: AIP Conference Proceedings 2021-03, Vol.2346 (1)
• Main Authors: Savitri, D. E., Evalisa, M., Nazir, F., Dwihapsari, Y.
• Format: Article
• Language: English
• Subjects: Age; Body size; Brain; Cameras; Correlation; Gamma rays; Image segmentation; Radiochemistry; Radioisotopes
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0048735

Brain scans have been conducted using gamma camera to determine the brain uptake value from anterior-posterior and lateral images and determine the correlation between injection dose, age, and Body Mass Index (BMI) on brain uptake. This study was performed on six volunteers with an average age of 58 ± 1 years old. Brain scans were performed using a dual-headed gamma camera, and the static images were obtained from anterior-posterior and lateral positions. In this study, the radioisotope was Tc99m mixed with Hexamethyl Propyleneamine Oxime (HMPAO) cold kit pharmaceutical. The average injection dose given to volunteers was 13.35 ± 1.59 mCi. Radiopharmaceutical was administered to volunteers through intravenous injection. 99mTc HMPAO inside the body will emit gamma radiation that will be detected by a gamma camera to produce images of the observed organ. The counts were obtained using segmentation of freehand region-of-interest (ROI) to obtain brain uptake value. The results showed that the uptake mean value from the anterior-posterior image was 3.11%, and the lateral image was 3.19%, respectively. The injection dose and age showed a weak correlation with brain uptake value, while BMI showed an inversely moderate correlation with 99mTc HMPAO uptake value.