Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs - biological activities and SAR studies

Isoquinoline alkaloids are a large group of natural products in which 1,2,3,4-tetrahydroisoquinolines (THIQ) form an important class. THIQ based natural and synthetic compounds exert diverse biological activities against various infective pathogens and neurodegenerative disorders. Due to these reaso...

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Bibliographic Details
Published in:RSC advances 2021-03, Vol.11 (2), p.12254-12287
Main Authors: Faheem, Karan Kumar, Banoth, Chandra Sekhar, Kondapalli Venkata Gowri, Chander, Subhash, Kunjiappan, Selvaraj, Murugesan, Sankaranarayanan
Format: Article
Language:English
Subjects:
Analogs
Biological activity
Chemistry
Natural products
Scaffolds
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Summary:Isoquinoline alkaloids are a large group of natural products in which 1,2,3,4-tetrahydroisoquinolines (THIQ) form an important class. THIQ based natural and synthetic compounds exert diverse biological activities against various infective pathogens and neurodegenerative disorders. Due to these reasons, the THIQ heterocyclic scaffold has garnered a lot of attention in the scientific community which has resulted in the development of novel THIQ analogs with potent biological activity. The present review provides a much-needed update on the biological potential of THIQ analogs, their structural-activity relationship (SAR), and their mechanism of action. In addition, a note on commonly used synthetic strategies for constructing the core scaffold has also been discussed. This review provides critical insights into the biological activities and Structure-Activity Relationship (SAR) studies of tetrahydroisoquinoline (THIQ) analogs.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra01480c