Prevalence, Molecular Epidemiology and Drug Resistance Pattern of Human Immunodeficiency Virus Type 1 among Injecting Drug Users in Lahore, Pakistan

Human immunodeficiency virus 1 (HIV-1) is common among injecting drug users (IDUs), and HIV-1 positive IDUs may have potential of HIV transmission among general population through different ways. Therefore, an understanding towards current status of HIV prevalence and genomic characteristics of circ...

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Bibliographic Details
Published in:Pakistan journal of zoology 2021-04, Vol.53 (2), p.563
Main Authors: Yaqub, Saima, Yaqub, Tahir, Shabbir, Muhammad Zubair, Nadeem, Asif, Rahman, Aziz-Ul, Shahid, Muhammad Furqan, Tahir, Zarfishan, Mukhtar, Nadia
Format: Article
Language:English
Subjects:
Algorithms
Antibodies
Antigens
Antiretroviral drugs
Developing countries
Disease control
Disease resistance
Disease transmission
Drug abuse
Drug resistance
Drug use
Epidemics
Epidemiology
Evolution & development
Genomes
Genotyping
Health aspects
Health risks
HIV
HIV (Viruses)
Human immunodeficiency virus
Infections
LDCs
Mutation
Phylogenetics
Phylogeny
Pol gene
Polymerase chain reaction
Population
Risk analysis
Risk factors
RNA-directed DNA polymerase
Sexually transmitted diseases
STD
Syringes
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Summary:Human immunodeficiency virus 1 (HIV-1) is common among injecting drug users (IDUs), and HIV-1 positive IDUs may have potential of HIV transmission among general population through different ways. Therefore, an understanding towards current status of HIV prevalence and genomic characteristics of circulating strains is crucial to devise and implement necessary interventions to control disease in developing countries like Pakistan. A total of 201 plasma samples were collected from IDUs. Samples were first screened using HIV-1 Ag/Ab Combo test and then antigen positive samples were amplified for HIV-1 pol gene (1084 bp) and analyzed. Initial screening showed a total of 49 HIV samples positive (24.37%; 95% CI: 18.96-30.76). A substantial association of HIV incidence was observed in individuals with HCV infection (36.84%; 95% CI: 28.55-45.99; p
ISSN:0030-9923
DOI:10.17582/journal.pjz/20200107110132