Effect of Quercetin on Rhinitis via Inflammatory Pathway

Asthma is a chronic inflammatory airway disease, characterized by reversible goblet cells, smooth muscle hyperplasia, airflow obstruction, hyperactivity enhanced, ultra-structural remodeling, and airway mucus production. The current experimental study was aimed at scrutinizing quercetin's inhib...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan journal of zoology 2021-04, Vol.53 (2), p.619
Main Authors: Xing, Yuan, Tan, Congming, Luo, Yan, Liu, Wenjun
Format: Article
Language:English
Subjects:
Air flow
Allergic diseases
Asthma
Body weight
Cytokines
Edema
Goblet cells
Granulation
Health aspects
Histamine
Hyperactivity
Hyperplasia
IL-1β
Immunoglobulin E
Interferon
Interleukin 4
Interleukin 5
Interleukin 6
Interleukins
Laboratories
Montelukast
Muscles
Nose
Parameters
Physiological aspects
Quercetin
Reagents
Respiratory tract diseases
Rhinitis
Smooth muscle
Software
Spleen
Tumor necrosis factor-α
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Asthma is a chronic inflammatory airway disease, characterized by reversible goblet cells, smooth muscle hyperplasia, airflow obstruction, hyperactivity enhanced, ultra-structural remodeling, and airway mucus production. The current experimental study was aimed at scrutinizing quercetin's inhibitory effect on airway inflammation in mice and its possible mechanism of action. The mice received varying doses of quercetin from 22-30 days (1, 10 and 50 mg/kg, p.o.) and montelukast (10 mg/kg, p.o.). Intranasal OVA has been instilled on the 21 days. Biochemical parameters, spleen weight, physiological parameters, interleukin (IL-1β and IL-6) parameters and immunoglobin-E (IgE) were calculated at the end of the experimental study. To investigate the potential mechanism of action, Paw edema and mast cell de-granulation are estimated. Used to measure immune and inflammatory mediators, qRT-PCR technique. Quercetin significantly (P
ISSN:0030-9923
DOI:10.17582/JOURNAL.PJZ/20190925070938