Procalcitonin-Guided Antibiotic Treatment in Lower Respiratory Tract Infections

Objective: Procalcitonin (PCT), C-reactive protein (CRP), and leukocyte count are important host response biomarkers to determine the presence of infection. The aim of the present study was to evaluate the usefulness of PCT with other markers in lower respiratory tract infections. Methods: A total o...

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Bibliographic Details
Published in:Journal of academic research in medicine 2018-08, Vol.8 (2), p.72-78
Main Authors: Kalamanoglu Balci, Merih, Balcan, Baran, Olgun Yildizeli, Sehnaz, Ceyhan, Berrin
Format: Article
Language:English
Subjects:
Antibiotics
Chronic obstructive pulmonary disease
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Summary:Objective: Procalcitonin (PCT), C-reactive protein (CRP), and leukocyte count are important host response biomarkers to determine the presence of infection. The aim of the present study was to evaluate the usefulness of PCT with other markers in lower respiratory tract infections. Methods: A total of 78 patients with community-acquired pneumonia (CAP), chronic obstructive pulmonary disease (COPD) exacerbations, and healthy controls were evaluated. Baseline serum levels of PCT and CRP and leukocyte counts were assessed and repeated on day 7 of antibiotic treatment. Results: Procalcitonin levels and absolute neutrophil counts (ANCs) were higher in the CAP and COPD groups than in the control group. In the CAP and COPD exacerbation groups, the leukocyte count, ANC, and CRP and PCT levels decreased on day 7 of the treatment (p
ISSN:2146-6505
2147-1894
DOI:10.5152/jarem.2018.1692