A repurposed, blood gene signature is associated with poor outcomes in SARS-CoV-2

Abstract Poor outcomes after SARS-CoV-2 infection are difficult to predict. Survivors may develop pulmonary fibrosis. We previously identified a 52-gene signature in peripheral blood, predictive of mortality in Idiopathic Pulmonary Fibrosis. In this study, we analyzed this signature in SARS-CoV-2 in...

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Bibliographic Details
Published in:bioRxiv 2020-11
Main Authors: Juan-Guardela, Brenda M, Sun, Jiehuan, Zhang, Tong, Xu, Bing, Michaud, Gaetane, Herazo-Maya, Jose D
Format: Article
Language:English
Subjects:
Dendritic cells
Erythrocytes
Fibrosis
Leukocytes (neutrophilic)
Lung diseases
Monocytes
Peripheral blood
Pulmonary fibrosis
Severe acute respiratory syndrome coronavirus 2
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Summary:Abstract Poor outcomes after SARS-CoV-2 infection are difficult to predict. Survivors may develop pulmonary fibrosis. We previously identified a 52-gene signature in peripheral blood, predictive of mortality in Idiopathic Pulmonary Fibrosis. In this study, we analyzed this signature in SARS-CoV-2 infected individuals and identified genomic risk profiles with significant differences in outcomes. Analysis of single cell expression data shows that monocytes, red blood cells, neutrophils and dendritic cells are the cellular source of the high risk gene signature. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2020.11.21.392670