Surgical Treatment for Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass: a Literature Review

Roux-en-Y gastric bypass (RYGB) is an effective treatment for severe obesity and obesity-related comorbidities. Postprandial hypoglycemia may occur as a long-term complication after RYGB. This study reviews the literature on surgical treatment for intractable post-RYGB hypoglycemia to provide update...

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Bibliographic Details
Published in:Obesity surgery 2021-04, Vol.31 (4), p.1801-1809
Main Authors: Xu, Qiang, Zou, Xi, You, Lei, Wu, Wenming, Zhu, Huijuan, Wang, Linjie, Yuan, Tao, Zhao, Yupei
Format: Article
Language:English
Subjects:
Gastric Bypass - adverse effects
Gastrointestinal surgery
Humans
Hypoglycemia
Hypoglycemia - etiology
Hypoglycemia - surgery
Medicine
Medicine & Public Health
Obesity, Morbid - surgery
Postprandial Period
Reoperation
Review
Surgery
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Summary:Roux-en-Y gastric bypass (RYGB) is an effective treatment for severe obesity and obesity-related comorbidities. Postprandial hypoglycemia may occur as a long-term complication after RYGB. This study reviews the literature on surgical treatment for intractable post-RYGB hypoglycemia to provide updated information. A search was performed in Embase and PubMed, and 25 papers were identified. Thirteen papers on reversal were included. Resolution of postprandial hypoglycemic symptoms occurred in 42/48 (88%) patients after reversal. Twelve papers on pancreatectomy were included. Resolution occurred in 27/50 (54%) patients after pancreatectomy. The optimal surgical treatment for intractable post-RYGB hypoglycemia has not been defined, but reversal of RYGB seems to be more effective than other treatments. Further research on etiology and long-term evaluation of surgical outcomes may refine treatment options.
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-021-05251-x