Lessons learned from the hypovitaminosis D kyphotic pig model

The hypovitaminosis D kyphotic pig model has allowed research into the cellular signals involved in the initiation and early development of bone and joint abnormalities. These lesions are consistent with the early stages of lesions of osteochondrosis (OC). Most studies of OC lesions have focused on...

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Published in:Journal of animal science 2020-08, Vol.98, p.S52-S57
Main Authors: Amundson, Laura A, Crenshaw, Thomas D
Format: Article
Language:English
Subjects:
Abnormalities
Biomedical materials
Laboratory animals
Lesions
Musculoskeletal diseases
Osteochondrosis
Studies
Vitamin deficiency
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Crenshaw, Thomas D
description The hypovitaminosis D kyphotic pig model has allowed research into the cellular signals involved in the initiation and early development of bone and joint abnormalities. These lesions are consistent with the early stages of lesions of osteochondrosis (OC). Most studies of OC lesions have focused on the characterization of the end-stage lesions as these abnormalities become clinically evident. Understanding the molecular events involved in the early stages of OC lesions and the molecular events affecting the progression of lesions to clinically relevant, end-stage lesions will allow the development of better methods to prevent and treat these musculoskeletal abnormalities. Here, Amundson and Crenshaw summarize the lessons learned from studies using the hypovitaminosis D kyphotic pig model.
doi_str_mv 10.1093/jas/skaal46
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subjects Abnormalities
Biomedical materials
Laboratory animals
Lesions
Musculoskeletal diseases
Osteochondrosis
Studies
Vitamin deficiency
title Lessons learned from the hypovitaminosis D kyphotic pig model
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