Investigations of Chirality Effects on Undifferentiated State of Mesenchymal Stem Cells Using Soft Nanofibrous Oligopeptide Hydrogels

Soft nanofibrous oligopeptide hydrogels consisting of self-assembled l- and d-form Fmoc-Phe-Phe-Cys networks photo-cross-linked by poly(ethylene glycol)-dimethacrylate, which are referred to as l- and d-gel, respectively, were developed for investigation of chirality effects on the undifferentiated...

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Bibliographic Details
Published in:Analytical Sciences 2021/03/10, Vol.37(3), pp.539-543
Main Authors: YOSHITOMI, Toru, ZHENG, Hangyu, YOSHIMOTO, Keitaro
Format: Article
Language:English
Subjects:
3D culture
Analytical Chemistry
cell spreading
Chemistry
Chirality
fibrous hydrogels
Humans
Hydrogels
Hydrogels - chemistry
mesenchymal stem cell
Mesenchymal stem cells
Mesenchymal Stem Cells - cytology
Nanofibers - chemistry
Oligopeptides - chemistry
peptide self-assembly
Polyethylene glycol
Regenerative medicine
Self-assembly
Stem cells
undifferentiated state
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Summary:Soft nanofibrous oligopeptide hydrogels consisting of self-assembled l- and d-form Fmoc-Phe-Phe-Cys networks photo-cross-linked by poly(ethylene glycol)-dimethacrylate, which are referred to as l- and d-gel, respectively, were developed for investigation of chirality effects on the undifferentiated state of mesenchymal stem cells. Encapsulated mesenchymal stem cells in d-gel showed slower growth and less spreading, resulting in higher maintenance of the undifferentiated state, compared to in l-gel. This indicates that d-form peptide materials might be useful as scaffold materials for regenerative medicine using stem cells.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.20SCN05