Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections

Worldwide emergence of Salmonella enterica serovar Newport (S. Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S. Newport resistance in China remains largely unknown. A...

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Bibliographic Details
Published in:Emerging microbes & infections 2020-01, Vol.9 (1), p.535-538
Main Authors: Elbediwi, Mohammed, Pan, Hang, Biswas, Silpak, Li, Yan, Yue, Min
Format: Article
Language:English
Subjects:
antimicrobial resistance
Colistin - pharmacology
colistin resistance
Drug Resistance, Bacterial
Humans
Letter
mcr-1
Salmonella
Salmonella enterica - drug effects
Salmonella enterica - isolation & purification
Salmonella Infections - microbiology
Salmonella Newport
seafood
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Summary:Worldwide emergence of Salmonella enterica serovar Newport (S. Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S. Newport resistance in China remains largely unknown. A retrospective study of 287 S. Newport clinical isolates collected during 1997-2018 was undertaken for characterization of AR profiles using the micro-dilution assay. We found a recent emergence of colistin resistance in four Chinese clinical isolates, including mcr-1-positive isolates. Importantly, phylogenomic and microbiological investigations indicate multiple independent clonal transmission of colistin-resistant S. Newport isolates of different seafood origins. Our study highlights potential reservoirs for transmission of colistin resistance and suggests that the global food supply chain may facilitate this dissemination.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2020.1733439