Gonococcal urethritis caused by a multidrug resistant Neisseria gonorrhoeae strain with high-level resistance to spectinomycin in China

We report a recent (2018) gonorrhoeal urethritis caused by a multidrug-resistant Neisseria gonorrhoeae strain in China. The isolated N. gonorrhoeae strain from a male and female pair expressed high-level resistance to spectinomycin (SPC), azithromycin, and other antibiotics but was sensitive to ceft...

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Bibliographic Details
Published in:Emerging microbes & infections 2020-01, Vol.9 (1), p.517-519
Main Authors: Chen, Shao-Chun, Hu, Li-Hua, Zhu, Xiao-Yu, Yin, Yue-Ping
Format: Article
Language:English
Subjects:
China
Drug Resistance, Multiple, Bacterial
Letter
Neisseria gonorrhoeae
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - genetics
Neisseria gonorrhoeae - metabolism
Penicillin
Phenotype
resistance
Ribosomal Proteins - genetics
Ribosomal Proteins - metabolism
spectinomycin
Spectinomycin - pharmacology
treatment failure
urethritis
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Summary:We report a recent (2018) gonorrhoeal urethritis caused by a multidrug-resistant Neisseria gonorrhoeae strain in China. The isolated N. gonorrhoeae strain from a male and female pair expressed high-level resistance to spectinomycin (SPC), azithromycin, and other antibiotics but was sensitive to ceftriaxone. The SPC high-level resistance (MIC = 2048 mg/L) was due to a small deletion in rspE that caused two amino acid changes in ribosomal protein S5.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2020.1732836