Quantitative Determination of Oxytetracycline in Water-Based Liquid Dosage Forms by Raman Spectroscopy

A universal method using Raman spectroscopy for the quantitative determination of oxytetracycline in three water-based medicines was developed. Five calibration models based on different mathematical data processing, i.e., one-dimensional calibration (Beer–Lambert law, classical least squares, stepw...

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Bibliographic Details
Published in:Journal of applied spectroscopy 2021-03, Vol.88 (1), p.108-113
Main Authors: Khrushchev, A. Yu, Akmaev, E. R., Bondarenko, V. O., Kis, I. V.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Atomic/Molecular Structure and Spectra
Bouguer law
Calibration
Data processing
Drug counterfeiting
Ethylenediaminetetraacetic acid
Least squares
Oxytetracycline
Physics
Physics and Astronomy
Povidone
Quality control
Quality management
Quantitative analysis
Raman spectroscopy
Spectrum analysis
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Summary:A universal method using Raman spectroscopy for the quantitative determination of oxytetracycline in three water-based medicines was developed. Five calibration models based on different mathematical data processing, i.e., one-dimensional calibration (Beer–Lambert law, classical least squares, stepwise multiple linear regression) and multi-dimensional calibration (partial least squares and principal component regression), were compared. The most accurate quantitative determinations were achieved when a calibration model based on partial least squares using two principal components was used.
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-021-01147-x