A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress

• Published in: Advanced functional materials 2021-03, Vol.31 (13), p.n/a
• Main Authors: Safaee, Mohammad Moein, Gravely, Mitchell, Roxbury, Daniel
• Format: Article
• Language: English
• Subjects: Biological activity; biomaterials; Biomedical materials; Encapsulation; Fluorescence; Free radicals; Hydrogen peroxide; infection; Materials science; Medical materials; Nanosensors; Optical properties; oxidative stress; Signal monitoring; Single wall carbon nanotubes; single‐walled carbon nanotubes; Structural integrity; Textiles; wearable biosensors; Wearable technology; Wound healing; wound monitoring
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.202006254

In an effort to facilitate personalized medical approaches, the continuous and noninvasive monitoring of biochemical information using wearable technologies can enable a detailed understanding of an individual's physiology. Reactive oxygen species (ROS) are a class of oxygen‐containing free radicals that function in a wide range of biological processes. In wound healing applications, the continuous monitoring of ROS through a wearable diagnostics platform is essential for the prevention of chronicity and pathogenic infection. Here, a versatile one‐step procedure is utilized to fabricate optical core‐shell microfibrous textiles incorporating single‐walled carbon nanotubes (SWCNTs) for the real‐time optical monitoring of hydrogen peroxide concentrations in in vitro wounds. The environmentally sensitive and non‐photobleachable fluorescence of SWCNTs enables continuous analyte monitoring without decay in signal over time. The existence of multiple chiralities of SWCNTs emitting near‐infrared fluorescence with narrow bandwidths allows a ratiometric signal readout invariant to the excitation source distance and exposure time. The individual fibers encapsulate the SWCNT nanosensors for at least 21 days without apparent loss in structural integrity. Moreover, the microfibrous textiles are utilized to spatially resolve peroxide concentrations using a camera and further integrated into commercial wound bandages without significant degradation in their optical properties. Optical core‐shell microfibrous textiles encapsulating single‐walled carbon nanotubes (SWCNTs) are fabricated utilizing a versatile one‐step process for real‐time and wireless monitoring of peroxide concentrations in wounds. The near‐infrared fluorescence from SWCNTs that is environmentally sensitive and non‐photobleachable enables continuous monitoring of biochemical analytes without signal decay over time.