Right ventricular dysfunction in patients with diffuse large B-cell lymphoma undergoing anthracycline-based chemotherapy: a 2D strain and 3D echocardiography study

To investigate whether 2D strain and 3D echocardiography could early identify the impaired right ventricular (RV) function after anthracycline exposure. Sixty-one patients with diffuse large B-cell lymphoma treated with anthracycline were studied. Echocardiography was conducted at baseline, after th...

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Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2021-04, Vol.37 (4), p.1311-1319
Main Authors: Wang, Baozhen, Yu, Yang, Zhang, Yue, Hao, Xiaoyi, Yang, Shan, Zhao, Hong, Sun, Qianqian, Wang, Yue
Format: Article
Language:English
Subjects:
Anthracycline
B-cell lymphoma
Cardiac Imaging
Cardiology
Cardiotoxicity
Chemotherapy
Echocardiography
Heart
Imaging
Lymphocytes B
Lymphoma
Medicine
Medicine & Public Health
Original Paper
Parameters
Radiology
Strain analysis
Ventricle
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Summary:To investigate whether 2D strain and 3D echocardiography could early identify the impaired right ventricular (RV) function after anthracycline exposure. Sixty-one patients with diffuse large B-cell lymphoma treated with anthracycline were studied. Echocardiography was conducted at baseline, after the third cycle of the chemotherapy, after the completion of the chemotherapy, and follow-up at 10 months after the initiation of chemotherapy. RV global longitudinal strain (RV GLS) and RV free wall longitudinal strain (RV FWLS) were calculated using speckle tracking echocardiography. RV ejection fraction (RVEF) was analyzed by 3D echocardiography. RV systolic dysfunction was defined by ≥ 2 RV parameters below the threshold value, and cardiotoxicity was defined as a reduction in left ventricular EF > 10 to 
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-020-02120-z