Transfusion‐associated hyperkalemia in pediatric population: Prevalence, risk factors, survival, infusion rate, and RBC unit features

Background Hyperkalemia is a rare life‐threatening complication of red blood cell (RBC) transfusion. Stored RBCs leak intracellular potassium (K+) into the supernatant; irradiation potentiates the K+ leak. As the characteristics of patients and implicated RBCs have not been studied systematically, a...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2021-04, Vol.61 (4), p.1093-1101
Main Authors: Yamada, Chisa, Edelson, Maureen, Lee, Angela, Saifee, Nabiha Huq, Bahar, Burak, Delaney, Meghan
Format: Article
Language:English
Subjects:
Adolescent
Blood transfusion
Blood volume
Case-Control Studies
Child
Child, Preschool
Comorbidity
Demographics
Demography
Erythrocyte Transfusion - adverse effects
Erythrocytes
Female
Humans
Hyperkalemia
Hyperkalemia - diagnosis
Hyperkalemia - epidemiology
Hyperkalemia - etiology
Hyperkalemia - mortality
Infant
Infusions, Intravenous - adverse effects
Infusions, Intravenous - statistics & numerical data
Irradiation
Male
Medical records
Mortality
Mortality - trends
non infectious
Patients
Pediatrics
Potassium
Potassium - blood
Prevalence
RBC transfusion
Retrospective Studies
Risk analysis
Risk Factors
Transfusion
transfusion complications
Transfusion Medicine - statistics & numerical data
transfusion practices (neonatal, pediatrics)
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Summary:Background Hyperkalemia is a rare life‐threatening complication of red blood cell (RBC) transfusion. Stored RBCs leak intracellular potassium (K+) into the supernatant; irradiation potentiates the K+ leak. As the characteristics of patients and implicated RBCs have not been studied systematically, a multicenter study of transfusion‐associated hyperkalemia (TAH) in the pediatric population was conducted through the AABB Pediatric Transfusion Medicine Subsection. Study Design The medical records of patients
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.16300