Regioselective Direct C2 Arylation of Indole, Benzothiophene and Benzofuran: Utilization of Reusable Pd NPs and NHC-Pd@MNPs Catalyst for C–H Activation Reaction

A regioselective C2 arylation of indoles, benzothiophene and benzofuran without directing group has been accomplished using economically cheap Pd NPs and NHC-Pd@MNPs catalyst. The reusable catalyst is efficiently employed to access C2 arylated heterocycles in good to excellent yield. The reusability...

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Bibliographic Details
Published in:Catalysis letters 2021-05, Vol.151 (5), p.1397-1405
Main Authors: Hegde, Rajeev V., Ong, Tiow-Gan, Ambre, Ram, Jadhav, Arvind H., Patil, Siddappa A., Dateer, Ramesh B.
Format: Article
Language:English
Subjects:
Benzothiophene
Catalysis
Catalysts
Chemistry
Chemistry and Materials Science
Indoles
Industrial Chemistry/Chemical Engineering
Organometallic Chemistry
Palladium
Palladium catalysts
Physical Chemistry
Reaction mechanisms
Regioselectivity
Thiophene
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Summary:A regioselective C2 arylation of indoles, benzothiophene and benzofuran without directing group has been accomplished using economically cheap Pd NPs and NHC-Pd@MNPs catalyst. The reusable catalyst is efficiently employed to access C2 arylated heterocycles in good to excellent yield. The reusability of the catalyst is studied up to five cycles and a gram-scale synthesis has been achieved. The reaction mechanism is well supported by control experiments and literature precedents. Grapic Abstract
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-020-03390-x