Functionalized crosslinked interpenetrating polymeric network for pH responsive colonic drug delivery

Current exploration unveils the promising role of arabinoxylan (AX) in targeted delivery of acid labile active moiety, by using methacrylic acid (MAA) as monomer, N′,N′-methylene-bis-acrylamide (MBA) as crosslinker and ammonium persulfate as initiator. Different feed composition of AX, MAA and MBA w...

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Bibliographic Details
Published in:International journal of polymeric materials 2021-06, Vol.70 (9), p.646-655
Main Authors: Azam, Farooq, Ijaz, Hira, Qureshi, Junaid
Format: Article
Language:English
Subjects:
Acrylamide
Ammonium peroxodisulfate
Arabinoxylan
Controlled release
Crosslinking
Drug delivery systems
Fourier transforms
Free radical polymerization
Free radicals
Hydrogels
Methacrylic acid
Methylene bisacrylamide
N′,N′-methylene-bis-acrylamide
Swelling ratio
Thermodynamic properties
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Summary:Current exploration unveils the promising role of arabinoxylan (AX) in targeted delivery of acid labile active moiety, by using methacrylic acid (MAA) as monomer, N′,N′-methylene-bis-acrylamide (MBA) as crosslinker and ammonium persulfate as initiator. Different feed composition of AX, MAA and MBA was blended to optimize hydrogels by free radical polymerization technique. Formulation AXMA2 showed maximum swelling and drug release at pH 7.4. Fourier transform infrared spectroscopy (FTIR) depicts crosslinking of MAA and AX based. Thermal characterization confirmed the formation of thermodynamically stable hybrid. However, morphological studies showed porous architecture. The pH sensitivity of hydrogels has been affirmed by swelling dynamics, equilibrium swelling ratio (ESR), on-off switching and drug release studies in acidic and alkaline pH. Drug release studies showed controlled release of the perindopril erbumine from polymeric network. Crosslinked AX nexus can be used as promising carrier for the configuring and formulating targeted drug-delivery systems.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2020.1740995