Dosimetric Comparison of Radiation Therapy Using Hybrid-VMAT Technique for Stage I Esophageal Cancer

This study focused on the hybrid-volumetric modulated arc therapy (hVMAT) for stage I esophageal cancer and compared the effects on dose distribution induced by changes in the ratio of three-dimensional conformal radiotherapy (3DCRT) to VMAT. Fifteen patients who underwent 3DCRT for cT1bN0M0 esophag...

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Bibliographic Details
Published in:Anticancer research 2021-04, Vol.41 (4), p.1951-1958
Main Authors: Takakusagi, Yosuke, Kusunoki, Terufumi, Kano, Kio, Anno, Wataru, Tsuchida, Keisuke, Mizoguchi, Nobutaka, Serizawa, Itsuko, Katoh, Hiroyuki, Kamada, Tadashi, Ezura, Takatomo, Shirai, Katsuyuki, Yoshida, Daisaku
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Cancer
Cancer therapies
Dose-Response Relationship, Radiation
Esophageal cancer
Esophageal Neoplasms - pathology
Esophageal Neoplasms - radiotherapy
Esophagus
Heart - radiation effects
Histograms
Homogeneity
Humans
Lung - radiation effects
Lungs
Matched-Pair Analysis
Neoplasm Staging
Organs
Organs at Risk
Parameters
Radiation
Radiation therapy
Radiometry - methods
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Conformal - adverse effects
Retrospective Studies
Tumor Burden - radiation effects
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Summary:This study focused on the hybrid-volumetric modulated arc therapy (hVMAT) for stage I esophageal cancer and compared the effects on dose distribution induced by changes in the ratio of three-dimensional conformal radiotherapy (3DCRT) to VMAT. Fifteen patients who underwent 3DCRT for cT1bN0M0 esophageal cancer at Kanagawa Cancer Center from January 2014 to April 2019 were included in the study. The dose-volume histogram (DVH) parameters of the target volume and normal organs were evaluated in the 3DCRT, hVMAT, and VMAT treatment plans. The homogeneity index of the target volume was significantly lower for hVMAT. In hVMAT, as the ratio of VMAT increased, the volume of low-dose region in the heart and lung increased, whereas the volume of the middle- to high-dose region decreased. As the ratio of VMAT increased, the mean dose in the heart decreased, whereas the mean dose in the lung increased. Favorable dose concentration was obtained for the target volume in hVMAT for stage I esophageal cancer. Altering the ratio of VMAT significantly changed the DVH parameters in normal organs.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.14962