Modification of WS2 nanosheets with beta-cyclodextrone and N-isopropylacrylamide polymers for tamoxifen adsorption and investigation of in vitro drug release

In this research, tungsten disulfide (WS 2 ) nanosheets were modified with beta-cyclodextrone (βCD) N-isopropylacrylamide polymers (NIPAAP) for adsorption of tamoxifen (TAM) drug. The synthesized WS 2 /βCD/NIPAAP samples were characterized by field-emission scanning electron microscopy (FE-SEM), Fou...

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Bibliographic Details
Published in:Research on chemical intermediates 2021-05, Vol.47 (5), p.1955-1978
Main Authors: Bohloli, Abbas, Asli, Maryam Daghighi, Moniri, Elham, Gh, Azar Bagheri
Format: Article
Language:English
Subjects:
Adsorption
Catalysis
Chemistry
Chemistry and Materials Science
Emission analysis
Fourier transforms
Infrared analysis
Inorganic Chemistry
Isopropylacrylamide
Nanosheets
Physical Chemistry
Polymers
Regeneration
Tamoxifen
Thermogravimetric analysis
Tungsten disulfide
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Summary:In this research, tungsten disulfide (WS 2 ) nanosheets were modified with beta-cyclodextrone (βCD) N-isopropylacrylamide polymers (NIPAAP) for adsorption of tamoxifen (TAM) drug. The synthesized WS 2 /βCD/NIPAAP samples were characterized by field-emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and X-ray diffraction (XRD) analyses. The adsorption experiments of TAM on WS 2 /βCD/NIPAAP were performed as a function of pH, reaction contact time, temperature and drug concentration. The adsorption kinetic data were well fitted to the pseudo-second-order model. Also, the equilibrium data were well described by Langmuir isotherm model. The maximum adsorption capacity of WS 2 /βCD/NIPAAP for TAM drug was found to be 62.0 mg/g. The results of regeneration tests showed that the synthesized WS 2 /βCD/NIPAAP adsorbent can be easily reused after 6 cycles of adsorption–desorption. Furthermore, TAM drug release was investigated in a simulated system with pH 7.4 at different temperatures. The results showed that the release of TAM drug from WS 2 /βCD/NIPAAP carrier at 50 °C and 37 °C was greater than TAM release at 25 °C. Also, the experimental data of drug release were studied by Higuchi, Ritger-Peppas, zero-order and first-order models. The release data were well fitted to the zero-order model indicating a case II transport. The results showed a high stability for TAM drug.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-020-04376-5