Antidepressant-Like Effect of Bupleurum Paeonia Liujunzi Decoction on Depression Model Mice and its mechanism

To investigate the behavioral effects and mechanisms of Bupleurum Paeonia Liujunzi Decoction (BPLD) in depression model mice. Twenty male Kunming mice were randomly divided into four groups: blank group, model group, fluoxetine group and Bupleurum Paeonia Liujunzi Decoums combined with reserpine gav...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2021-03, Vol.714 (3), p.32046
Main Authors: Xing, Zhiyu, Liu, Shengli, Xu, Chang, Xiao, Junke, Liu, Jihong, Li, Li, Gao, Xiaoyao, Wang, Zirui, Zheng, Qingting, He, Yuting, Lv, Shaohui, Gao, Chaopeng, Li, Xiaobing
Format: Article
Language:English
Subjects:
Animal models
Antidepressants
Benzodiazepines
Body weight
Bupleurum
Diazepam
Dopamine
Fluoxetine
Herbal medicine
Mental depression
Norepinephrine
Paeonia
Reserpine
Serum levels
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Summary:To investigate the behavioral effects and mechanisms of Bupleurum Paeonia Liujunzi Decoction (BPLD) in depression model mice. Twenty male Kunming mice were randomly divided into four groups: blank group, model group, fluoxetine group and Bupleurum Paeonia Liujunzi Decoums combined with reserpine gavage. Fluoxetine group were given fluoxetine treatment at 2mg/kg/d and Bupleurum Paeonia Liujunzi Decoctiction group. Depression model mice were induced by the chronic unpredictable mild stress (Con group were given BPLD treatment at 8g/kg/d. The model group and the blank group were given normal saline once a day. The experiment lasted for 7 days, during which the general state (body weight, hair color, etc.) was recorded and the changes were observed. The serum levels of norepinephrine (NE) and dopamine (DA) were detected by ELISA kit. Compared with the model group, the body weights of the diazepam group and the Chinese medicine group were significantly increased (P
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/714/3/032046