Synthesis, characterization, and activity of 6-(10H-phenothiazine-10-yl)-1H,3H-benzo[de]-isochromen-1,3-dione derivative of 4-aminophenylacetic acid

The objective of the present paper was to study the synthesis of a new compound 6-(10H-phenothiazme-10-yl)-1H,3H-benzo[de]-isochromen-1,3-dione derivative of 4-aminophenylacetic acid (PTZD). Its physicochemical characteristics and spectral data were presented. PTZD was found to have good inhibitory...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2021-01, Vol.1031 (1), p.12111
Main Authors: Haralanova, T, Marinov, M, Kostova, I, Nikolova, I, Damyanova, S, Stoyanov, N
Format: Article
Language:English
Subjects:
antimicrobial activity
Bacteria
corrosion
Diketones
E coli
Fungicides
Gram-positive bacteria
phenothiazine
Synthesis
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Summary:The objective of the present paper was to study the synthesis of a new compound 6-(10H-phenothiazme-10-yl)-1H,3H-benzo[de]-isochromen-1,3-dione derivative of 4-aminophenylacetic acid (PTZD). Its physicochemical characteristics and spectral data were presented. PTZD was found to have good inhibitory activity. The phenothiazine derivative showed good fungicidal activity against the studied yeast (S. cerevisiae and C. albicans) and mold species (A. brasiliensis and F. moniliforme), weak bactericidal activity against the Gram-positive bacteria S. aureus and B. subtilis and did not affect the growth of Gram-negative bacteria E. coli, P. aeruginosa and S. abony.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/1031/1/012111