Supratentorial ependymoma with YAP1:FAM118B fusion: A case report

We report a case of a 26‐year‐old Chinese man who had experienced three grand mal seizures in the past two months. Magnetic resonance imaging revealed a relatively well‐circumscribed lesion in the left frontal lobe. A craniotomy with total excision of the tumor was performed. Histopathological inves...

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Bibliographic Details
Published in:Neuropathology 2021-04, Vol.41 (2), p.133-138
Main Authors: Wang, Jian, Wang, Liang, Fu, Lin, Li, Qing‐Chang, Qiu, Xue‐Shan, Wang, En‐Hua, Yu, Juan‐Han
Format: Article
Language:English
Subjects:
Case reports
DNA methylation
DNA methyltransferase
ependymoma
Frontal lobe
Genetic analysis
Magnetic resonance imaging
Methylguanine
molecular classification
neuroepithelial neoplasm
Seizures
supratentorial
YAP1‐FAM118B fusion
Yes-associated protein
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Summary:We report a case of a 26‐year‐old Chinese man who had experienced three grand mal seizures in the past two months. Magnetic resonance imaging revealed a relatively well‐circumscribed lesion in the left frontal lobe. A craniotomy with total excision of the tumor was performed. Histopathological investigations confirmed a grade 2 ependymoma according to the World Health Organization classification. Genetic analysis revealed a tumor harboring FAM118B fusion to YAP1, and no other genetic alterations or methylation of the O6‐methylguanine‐DNA methyltransferase gene promoter were detected. This is the second case report of ependymoma with YAP1:FAM118B fusion.
ISSN:0919-6544
1440-1789
DOI:10.1111/neup.12712