Data science and molecular biology: prediction and mechanistic explanation

In the last few years, biologists and computer scientists have claimed that the introduction of data science techniques in molecular biology has changed the characteristics and the aims of typical outputs (i.e. models) of such a discipline. In this paper we will critically examine this claim. First,...

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Bibliographic Details
Published in:Synthese (Dordrecht) 2021-04, Vol.198 (4), p.3131-3156
Main Authors: López-Rubio, Ezequiel, Ratti, Emanuele
Format: Article
Language:English
Subjects:
Artificial intelligence
Biology
Cancer
Data analysis
Data science
Education
Epistemology
Logic
Machine learning
Metaphysics
Molecular biology
Philosophy
Philosophy of Language
Philosophy of Science
Predictions
Science
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Summary:In the last few years, biologists and computer scientists have claimed that the introduction of data science techniques in molecular biology has changed the characteristics and the aims of typical outputs (i.e. models) of such a discipline. In this paper we will critically examine this claim. First, we identify the received view on models and their aims in molecular biology. Models in molecular biology are mechanistic and explanatory. Next, we identify the scope and aims of data science (machine learning in particular). These lie mainly in the creation of predictive models which performances increase as data set increases. Next, we will identify a tradeoff between predictive and explanatory performances by comparing the features of mechanistic and predictive models. Finally, we show how this a priori analysis of machine learning and mechanistic research applies to actual biological practice. This will be done by analyzing the publications of a consortium—The Cancer Genome Atlas—which stands at the forefront in integrating data science and molecular biology. The result will be that biologists have to deal with the tradeoff between explaining and predicting that we have identified, and hence the explanatory force of the ‘new’ biology is substantially diminished if compared to the ‘old’ biology. However, this aspect also emphasizes the existence of other research goals which make predictive force independent from explanation.
ISSN:0039-7857
1573-0964
DOI:10.1007/s11229-019-02271-0