KI catalyzed C-H functionalization of acetone for the synthesis of 2-oxopropyl hetero-aromatic carboxylates

KI catalyzed C-H functionalization of acetone with hetero-aromatic carboxylic acids has been developed. With potassium iodide as catalyst and sodium chlorite as oxidant, cascade reaction including α-H electrophilic substitution of acetone and nucleophilic substitution of iodoacetone occur smoothly....

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Bibliographic Details
Published in:Synthetic communications 2021-05, Vol.51 (10), p.1556-1563
Main Authors: Zhou, Xiao-Yu, Chen, Xia, Liu, Hai-Long
Format: Article
Language:English
Subjects:
Acetone
C-H functionalization
Carboxylates
Carboxylic acids
Cascade chemical reactions
catalysis
Chemical synthesis
iodide
Oxidizing agents
oxopropyl carboxylates
Potassium iodides
Substitution reactions
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Summary:KI catalyzed C-H functionalization of acetone with hetero-aromatic carboxylic acids has been developed. With potassium iodide as catalyst and sodium chlorite as oxidant, cascade reaction including α-H electrophilic substitution of acetone and nucleophilic substitution of iodoacetone occur smoothly. 2-Oxopropyl hetero-aromatic carboxylates are obtained with the good to excellent yields.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2021.1892762