Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer treatment have attracted increasing attention in the past few years. This review will summarize the state of the art of des...

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Bibliographic Details
Published in:Nanoscale 2021-04, Vol.13 (15), p.718-7118
Main Authors: Qin, Jingbo, Gong, Ningqiang, Liao, Zhihuan, Zhang, Shouwen, Timashev, Peter, Huo, Shuaidong, Liang, Xing-Jie
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Cancer therapies
DNA, Mitochondrial
Interference
Mitochondria
Mitochondrial DNA
Nanotechnology
Neoplasms - drug therapy
Reactive Oxygen Species
State-of-the-art reviews
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Summary:Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer treatment have attracted increasing attention in the past few years. This review will summarize the state of the art of design and construction of nanosystems used for mitochondria-targeted delivery. The use of nanotechnology for cancer treatment through various pathways such as energy metabolism interference, reactive oxygen species (ROS) regulation, mitochondrial protein targeting, mitochondrial DNA (mtDNA) interference, mitophagy inducing, and combination therapy will be discussed. Finally, the major challenges and an outlook in this field will also be provided. This review summarizes the state of the art design and construction of nanosystems used for mitochondria-targeted delivery.
ISSN:2040-3364
2040-3372
DOI:10.1039/d1nr01068a