Novel Adsorbents for Hydrophilic Chromatography Based on Silica Gel Covalently Modified with Poly(ethylene glycol)

Novel stationary phases based on aminopropyl silica gel covalently modified with poly(ethylene glycol) (PEG) with different matrix-to-polymer mass ratios are obtained. The chromatographic properties of the adsorbents are studied using the Tanaka test procedure for hydrophilic stationary phases (and...

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Bibliographic Details
Published in:Moscow University chemistry bulletin 2021, Vol.76 (1), p.75-84
Main Authors: Popov, A. S., Maksimov, G. S., Smolenkov, A. D., Shpigun, O. A., Chernobrovkina, A. V.
Format: Article
Language:English
Subjects:
Adsorbents
Amino acids
Aminopropyl silica
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chromatography
Hydrophilicity
Liquid chromatography
Mass ratios
Polyethylene glycol
Selectivity
Silica gel
Silicon dioxide
Sugar
Thickness
Vitamins
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Summary:Novel stationary phases based on aminopropyl silica gel covalently modified with poly(ethylene glycol) (PEG) with different matrix-to-polymer mass ratios are obtained. The chromatographic properties of the adsorbents are studied using the Tanaka test procedure for hydrophilic stationary phases (and by way of example of separating model mixtures of sugars, amino acids, and water-soluble vitamins). It is shown that varying the thickness of the layer of (PEG) not only affects the efficiency but also makes it possible to tailor the selectivity toward polar analytes in the hydrophilic interaction liquid chromatography mode.
ISSN:0027-1314
1935-0260
DOI:10.3103/S0027131421010132