The Sigma-1 Receptor Ligand Chlorpromazine Attenuates Store-Dependent Ca2+ Entry in Peritoneal Macrophages

Using Fura-2AM, a fluorescent Ca 2+ indicator, we have shown for the first time that sigma-1 receptor antagonist - neuroleptic chlorpromazine - significantly inhibits the store-dependent Ca 2+ entry induced by immunomodulators glutoxim as well as molixan and endoplasmic reticulum Са 2+ -ATPase inhi-...

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Bibliographic Details
Published in:Biophysics (Oxford) 2021, Vol.66 (1), p.77-83
Main Authors: Milenina, L. S., Krutetskaya, Z. I., Antonov, V. G., Krutetskaya, N. I.
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Biological and Medical Physics
Biophysics
Calcium imaging
Calcium influx
Cell Biophysics
Chlorpromazine
Cyclopiazonic acid
Endoplasmic reticulum
Immunomodulation
Macrophages
Peritoneum
Physics
Physics and Astronomy
Thapsigargin
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Summary:Using Fura-2AM, a fluorescent Ca 2+ indicator, we have shown for the first time that sigma-1 receptor antagonist - neuroleptic chlorpromazine - significantly inhibits the store-dependent Ca 2+ entry induced by immunomodulators glutoxim as well as molixan and endoplasmic reticulum Са 2+ -ATPase inhi-bitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in the regulation of store-dependent Ca 2+ entry in macrophages.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350921010115