P35 Outcomes in children with primary sclerosing cholangitis or autoimmune hepatitis-overlap and associated inflammatory bowel disease

BackgroundPrimary Sclerosing Cholangitis (PSC) and Autoimmune liver disease (autoimmune hepatitis & overlap syndrome (AIHO)) are rare entities. PSC and AIHO have been reported to be associated with IBD.AimTo study outcomes of children diagnosed with AIHO and PSC who also have a diagnosis of infl...

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Bibliographic Details
Published in:Frontline gastroenterology 2021-04, Vol.12 (Suppl 1), p.A31-A32
Main Authors: Jayaprakash, Kavitha, Paling, Ellen, Bradshaw, Olivia, Mtegha, Marumbo
Format: Article
Language:English
Subjects:
Age
Biological products
Hepatitis
Hypertension
Inflammatory bowel disease
Liver
Patients
Transplants & implants
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Summary:BackgroundPrimary Sclerosing Cholangitis (PSC) and Autoimmune liver disease (autoimmune hepatitis & overlap syndrome (AIHO)) are rare entities. PSC and AIHO have been reported to be associated with IBD.AimTo study outcomes of children diagnosed with AIHO and PSC who also have a diagnosis of inflammatory bowel disease (IBD). Outcomes included portal hypertension, biochemical remission, survival of native liver and mortality.MethodsThis is a retrospective study (2000–2020) of 193 patients diagnosed with AIH. Of these, 23 patients (14M:9F) had diagnosis of either AIHO+IBD or PSC+IBD. None had AIH without overlap. Case notes were examined at intervals of 1,3,5,7 and 10 years. Data included treatment modality, biochemical remission (ALT
ISSN:2041-4137
2041-4145
DOI:10.1136/flgastro-2021-bspghan.44