Network analysis in aged C. elegans reveals candidate regulatory genes of ageing

Ageing is a biological process guided by genetic and environmental factors that ultimately lead to adverse outcomes for organismal lifespan and healthspan. Determination of molecular pathways that are affected with age and increase disease susceptibility is crucial. The gene expression profile of th...

Full description

Saved in:
Bibliographic Details
Published in:Biogerontology (Dordrecht) 2021-06, Vol.22 (3), p.345-367
Main Authors: Aktypi, Foteini, Papaevgeniou, Nikoletta, Voutetakis, Konstantinos, Chatziioannou, Aristotelis, Grune, Tilman, Chondrogianni, Niki
Format: Article
Language:English
Subjects:
Aging
Biomedical and Life Sciences
Cell Biology
Developmental Biology
DNA microarrays
Environmental factors
Gene expression
Geriatrics/Gerontology
Life Sciences
Life span
Research Article
Worms
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ageing is a biological process guided by genetic and environmental factors that ultimately lead to adverse outcomes for organismal lifespan and healthspan. Determination of molecular pathways that are affected with age and increase disease susceptibility is crucial. The gene expression profile of the ideal ageing model, namely the nematode Caenorhabditis elegans mapped with the microarray technology initially led to the identification of age-dependent gene expression alterations that characterize the nematode's ageing process. The list of differentially expressed genes was then utilized to construct a network of molecular interactions with their first neighbors/interactors using the interactions listed in the WormBase database. The subsequent network analysis resulted in the unbiased selection of 110 candidate genes, among which well-known ageing regulators appeared. More importantly, our approach revealed candidates that have never been linked to ageing before, thus suggesting promising potential targets/ageing regulators.
ISSN:1389-5729
1573-6768
DOI:10.1007/s10522-021-09920-3