Dosimetry in fractionated irradiation of rat brain to evaluate radiobiological response

Radiotherapy represents a significant part of the treatment for glioblastoma multiforme and consists of 30 fractions of 2 Gy for 6 to 7 weeks. However, in preclinical studies, many different irradiation schedules are used. The aim of this work was to evaluate brain radiotoxicity from a fractionated...

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Bibliographic Details
Main Authors: Ojeda, Abril Damaris Iglesias, Munive, Monserrat Llaguno, Ramirez, Efrén Hernández, Velázquez, Luis Alberto Medina
Format: Conference Proceeding
Language:English
Subjects:
Brain
Computed tomography
Dosimeters
Dosimetry
Irradiation
Radiation therapy
Rodents
Schedules
Weight loss
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Summary:Radiotherapy represents a significant part of the treatment for glioblastoma multiforme and consists of 30 fractions of 2 Gy for 6 to 7 weeks. However, in preclinical studies, many different irradiation schedules are used. The aim of this work was to evaluate brain radiotoxicity from a fractionated irradiation in rat brain to establish a preclinical model that allows the evaluation of the radiobiological response in a model of glioblastoma in rats irradiated with a 6 MV LINAC. Three groups of Wistar rats were irradiated once a week for 3 weeks achieving a total dose of 10, 15 and 20 Gy, respectively. Brain radiotoxicity was evaluated by weight loss, histological techniques and the 18-FDG uptakes determined by microPET/CT images between pre and post-irradiation groups. The results suggest that no significant differences in the radiotoxicity response between different fractionated doses were observed indicating a favourable result that will be used in the irradiation plan of the tumor model.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0051374