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Evaluation of topographic, tomographic, topometric, densitometric, and aberrometric features of cornea with pentacam HR system in subclinical keratoconus
Purpose To investigate topographic, tomographic, topometric, densitometric, and aberrometric parameters in subclinical keratoconus with the Pentacam HR imaging system. Methods Data of 3128 patients were evaluated, finding in 108 patients clinical keratoconus in one eye and subclinical keratoconus in...
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| Published in: | International ophthalmology 2021-05, Vol.41 (5), p.1729-1741 |
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| container_issue | 5 |
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| container_title | International ophthalmology |
| container_volume | 41 |
| creator | Ozkan, Haci Hasan Koc, Mustafa Kiziltoprak, Hasan Tekin, Kemal Aydemir, Emre |
| description | Purpose
To investigate topographic, tomographic, topometric, densitometric, and aberrometric parameters in subclinical keratoconus with the Pentacam HR imaging system.
Methods
Data of 3128 patients were evaluated, finding in 108 patients clinical keratoconus in one eye and subclinical keratoconus in the other. Corneal topographic, tomographic, topometric, densitometric, and aberrometric values obtained using the Pentacam HR imaging system were compared between clinical keratoconus, subclinical keratoconus, and normal eyes.
Results
Comparing eyes with subclinical keratoconus and the control group, while flat K, horizontal coma, horizontal trefoil, and vertical trefoil values were similar (
p
> 0.05 for each), all other parameters were significantly different (
p
|
| doi_str_mv | 10.1007/s10792-021-01732-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2520044523</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2520044523</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-b77969e66d4a672cf4d7dd499fad2fa7bb81c57736534611defe9c1b1af9ff1d3</originalsourceid><addsrcrecordid>eNp9UcFuFDEMjRCILoUf4IAicWUgTmYmzBFVhSJVQqrac-RJnHbKTjIkmaJ-Cn9Lll0Kp57sZz8_y36MvQbxHoTQHzIIPchGSGgEaCUbeMI20GnVyF6Jp2wjoO-aTgs4Yi9yvhVCDHron7MjpbSWtb5hv07vcLtimWLg0fMSl3idcLmZ7LsK5v_BEmcqaZc7CnkqDxCD4zhSSocK94RlTZR3ijamQMh_TuWGLxQKWpz52QXP97nQzKfA8zra7RQmi1v-nRKWaGNY80v2zOM206tDPGZXn08vT86a829fvp58Om-s0l1pRl1PGqjvXYu9lta3TjvXDoNHJz3qcfwIttNa9Z1qewBHngYLI6AfvAenjtnbve6S4o-VcjG3cU2hrjSyk0K0bSdVZck9y6aYcyJvljTNmO4NCLNzw-zdMNUN88cNA3XozUF6HWdyDyN_318Jak_ItRWuKf3b_Yjsb7EqmVo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2520044523</pqid></control><display><type>article</type><title>Evaluation of topographic, tomographic, topometric, densitometric, and aberrometric features of cornea with pentacam HR system in subclinical keratoconus</title><source>Springer Link</source><creator>Ozkan, Haci Hasan ; Koc, Mustafa ; Kiziltoprak, Hasan ; Tekin, Kemal ; Aydemir, Emre</creator><creatorcontrib>Ozkan, Haci Hasan ; Koc, Mustafa ; Kiziltoprak, Hasan ; Tekin, Kemal ; Aydemir, Emre</creatorcontrib><description>Purpose
To investigate topographic, tomographic, topometric, densitometric, and aberrometric parameters in subclinical keratoconus with the Pentacam HR imaging system.
Methods
Data of 3128 patients were evaluated, finding in 108 patients clinical keratoconus in one eye and subclinical keratoconus in the other. Corneal topographic, tomographic, topometric, densitometric, and aberrometric values obtained using the Pentacam HR imaging system were compared between clinical keratoconus, subclinical keratoconus, and normal eyes.
Results
Comparing eyes with subclinical keratoconus and the control group, while flat K, horizontal coma, horizontal trefoil, and vertical trefoil values were similar (
p
> 0.05 for each), all other parameters were significantly different (
p
< 0.05 for each). Densitometry values of eyes with subclinical keratoconus were significantly higher in all layers of the 0–2 mm annular area and in the anterior and central layers of the 2–6 mm annular area compared to the control group (
p
< 0.05 for each). According to the receiver operating characteristic curve analysis, the densitometry region with the largest area under the curve was the anterior layer of the 0–2 mm annular area. The sensitivity in this region was 79.4% and the specificity 73.2% in distinguishing eyes with subclinical keratoconus from normal eyes when 19.3 GSU was considered the threshold.
Conclusion
Corneal densitometry values in the 0–2 and 2–6 mm annular areas, especially in the anterior layers, are parameters that can be used to predict and distinguish subclinical keratoconus from normal eyes.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-021-01732-1</identifier><identifier>PMID: 33772701</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Cornea ; Densitometers ; Densitometry ; Eye (anatomy) ; Keratoconus ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Paper ; Parameters ; Topography</subject><ispartof>International ophthalmology, 2021-05, Vol.41 (5), p.1729-1741</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-b77969e66d4a672cf4d7dd499fad2fa7bb81c57736534611defe9c1b1af9ff1d3</citedby><cites>FETCH-LOGICAL-c375t-b77969e66d4a672cf4d7dd499fad2fa7bb81c57736534611defe9c1b1af9ff1d3</cites><orcidid>0000-0002-6896-2949</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33772701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozkan, Haci Hasan</creatorcontrib><creatorcontrib>Koc, Mustafa</creatorcontrib><creatorcontrib>Kiziltoprak, Hasan</creatorcontrib><creatorcontrib>Tekin, Kemal</creatorcontrib><creatorcontrib>Aydemir, Emre</creatorcontrib><title>Evaluation of topographic, tomographic, topometric, densitometric, and aberrometric features of cornea with pentacam HR system in subclinical keratoconus</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To investigate topographic, tomographic, topometric, densitometric, and aberrometric parameters in subclinical keratoconus with the Pentacam HR imaging system.
Methods
Data of 3128 patients were evaluated, finding in 108 patients clinical keratoconus in one eye and subclinical keratoconus in the other. Corneal topographic, tomographic, topometric, densitometric, and aberrometric values obtained using the Pentacam HR imaging system were compared between clinical keratoconus, subclinical keratoconus, and normal eyes.
Results
Comparing eyes with subclinical keratoconus and the control group, while flat K, horizontal coma, horizontal trefoil, and vertical trefoil values were similar (
p
> 0.05 for each), all other parameters were significantly different (
p
< 0.05 for each). Densitometry values of eyes with subclinical keratoconus were significantly higher in all layers of the 0–2 mm annular area and in the anterior and central layers of the 2–6 mm annular area compared to the control group (
p
< 0.05 for each). According to the receiver operating characteristic curve analysis, the densitometry region with the largest area under the curve was the anterior layer of the 0–2 mm annular area. The sensitivity in this region was 79.4% and the specificity 73.2% in distinguishing eyes with subclinical keratoconus from normal eyes when 19.3 GSU was considered the threshold.
Conclusion
Corneal densitometry values in the 0–2 and 2–6 mm annular areas, especially in the anterior layers, are parameters that can be used to predict and distinguish subclinical keratoconus from normal eyes.</description><subject>Cornea</subject><subject>Densitometers</subject><subject>Densitometry</subject><subject>Eye (anatomy)</subject><subject>Keratoconus</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Parameters</subject><subject>Topography</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UcFuFDEMjRCILoUf4IAicWUgTmYmzBFVhSJVQqrac-RJnHbKTjIkmaJ-Cn9Lll0Kp57sZz8_y36MvQbxHoTQHzIIPchGSGgEaCUbeMI20GnVyF6Jp2wjoO-aTgs4Yi9yvhVCDHron7MjpbSWtb5hv07vcLtimWLg0fMSl3idcLmZ7LsK5v_BEmcqaZc7CnkqDxCD4zhSSocK94RlTZR3ijamQMh_TuWGLxQKWpz52QXP97nQzKfA8zra7RQmi1v-nRKWaGNY80v2zOM206tDPGZXn08vT86a829fvp58Om-s0l1pRl1PGqjvXYu9lta3TjvXDoNHJz3qcfwIttNa9Z1qewBHngYLI6AfvAenjtnbve6S4o-VcjG3cU2hrjSyk0K0bSdVZck9y6aYcyJvljTNmO4NCLNzw-zdMNUN88cNA3XozUF6HWdyDyN_318Jak_ItRWuKf3b_Yjsb7EqmVo</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Ozkan, Haci Hasan</creator><creator>Koc, Mustafa</creator><creator>Kiziltoprak, Hasan</creator><creator>Tekin, Kemal</creator><creator>Aydemir, Emre</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0002-6896-2949</orcidid></search><sort><creationdate>20210501</creationdate><title>Evaluation of topographic, tomographic, topometric, densitometric, and aberrometric features of cornea with pentacam HR system in subclinical keratoconus</title><author>Ozkan, Haci Hasan ; Koc, Mustafa ; Kiziltoprak, Hasan ; Tekin, Kemal ; Aydemir, Emre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-b77969e66d4a672cf4d7dd499fad2fa7bb81c57736534611defe9c1b1af9ff1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cornea</topic><topic>Densitometers</topic><topic>Densitometry</topic><topic>Eye (anatomy)</topic><topic>Keratoconus</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Parameters</topic><topic>Topography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozkan, Haci Hasan</creatorcontrib><creatorcontrib>Koc, Mustafa</creatorcontrib><creatorcontrib>Kiziltoprak, Hasan</creatorcontrib><creatorcontrib>Tekin, Kemal</creatorcontrib><creatorcontrib>Aydemir, Emre</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozkan, Haci Hasan</au><au>Koc, Mustafa</au><au>Kiziltoprak, Hasan</au><au>Tekin, Kemal</au><au>Aydemir, Emre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of topographic, tomographic, topometric, densitometric, and aberrometric features of cornea with pentacam HR system in subclinical keratoconus</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>41</volume><issue>5</issue><spage>1729</spage><epage>1741</epage><pages>1729-1741</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To investigate topographic, tomographic, topometric, densitometric, and aberrometric parameters in subclinical keratoconus with the Pentacam HR imaging system.
Methods
Data of 3128 patients were evaluated, finding in 108 patients clinical keratoconus in one eye and subclinical keratoconus in the other. Corneal topographic, tomographic, topometric, densitometric, and aberrometric values obtained using the Pentacam HR imaging system were compared between clinical keratoconus, subclinical keratoconus, and normal eyes.
Results
Comparing eyes with subclinical keratoconus and the control group, while flat K, horizontal coma, horizontal trefoil, and vertical trefoil values were similar (
p
> 0.05 for each), all other parameters were significantly different (
p
< 0.05 for each). Densitometry values of eyes with subclinical keratoconus were significantly higher in all layers of the 0–2 mm annular area and in the anterior and central layers of the 2–6 mm annular area compared to the control group (
p
< 0.05 for each). According to the receiver operating characteristic curve analysis, the densitometry region with the largest area under the curve was the anterior layer of the 0–2 mm annular area. The sensitivity in this region was 79.4% and the specificity 73.2% in distinguishing eyes with subclinical keratoconus from normal eyes when 19.3 GSU was considered the threshold.
Conclusion
Corneal densitometry values in the 0–2 and 2–6 mm annular areas, especially in the anterior layers, are parameters that can be used to predict and distinguish subclinical keratoconus from normal eyes.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33772701</pmid><doi>10.1007/s10792-021-01732-1</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-6896-2949</orcidid></addata></record> |
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| subjects | Cornea Densitometers Densitometry Eye (anatomy) Keratoconus Medicine Medicine & Public Health Ophthalmology Original Paper Parameters Topography |
| title | Evaluation of topographic, tomographic, topometric, densitometric, and aberrometric features of cornea with pentacam HR system in subclinical keratoconus |
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