Effects of non-drug treatment on liver cells apoptosis during hepatic ischemia-reperfusion injury

Hepatic ischemia reperfusion injury (HIRI) is an important cause of liver dysfunction after liver transplantation for the patients suffered from fatty liver, non-alcoholic cirrhosis, or liver cancer. It is closely related to liver cells apoptosis. Therefore, how to maintain the stable state of cell...

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Bibliographic Details
Published in:Life sciences (1973) 2021-06, Vol.275, p.119321, Article 119321
Main Authors: Wang, Pei-pei, Huang, Xia, Yang, Mei-wen, Fang, Shi-yao, Hong, Fen-fang, Yang, Shu-long
Format: Article
Language:English
Subjects:
Apoptosis
Cirrhosis
Damage
Fatty liver
Hepatocytes
Humans
Inhalation
Ischemia
Ischemia reperfusion injury
Liver
Liver - blood supply
Liver - pathology
Liver cancer
Liver cirrhosis
Liver diseases
Liver transplantation
Liver Transplantation - adverse effects
Liver Transplantation - methods
Non-drug treatment
Perfusion
Preconditioning
Reperfusion
Reperfusion Injury - prevention & control
Respiration
Side effects
Signal transduction
Transplantation
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Summary:Hepatic ischemia reperfusion injury (HIRI) is an important cause of liver dysfunction after liver transplantation for the patients suffered from fatty liver, non-alcoholic cirrhosis, or liver cancer. It is closely related to liver cells apoptosis. Therefore, how to maintain the stable state of cell apoptosis is important to protect the liver from HIRI. Drug treatment basically applies some active substances directly or indirectly, reducing HIRI. But their toxic side effects limit the clinical applications. Differently, non-drug treatment means making use of other kinds of measures to reduce the damage, such as non-pharmaceutical preparations, surgical methods, inhalation or perfusion gas, and so on. Non-drug treatments have been shown to balance cell apoptosis and reduce liver damage during HIRI. This review summarized the progresses in the roles of non-drug treatments on liver cells apoptosis during HIRI in recent years, focusing on apoptosis inducing factors, its signal transduction pathway, and downstream molecules, etc., expecting to elucidate non-drug treatments of anti-HIRI more systematically. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2021.119321