Disposable and portable gold nanoparticles modified - laser-scribed graphene sensing strips for electrochemical, non-enzymatic detection of glucose

Glucose is one of the most important metabolites and a primary nutrient in human body metabolism. Abnormal levels of glucose can cause diabetes mellitus and related complications. Here, we developed a disposable and portable non-enzymatic glucose sensor strip based on gold-nanoparticles (AuNPs)-modi...

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Bibliographic Details
Published in:Electrochimica acta 2021-05, Vol.378, p.138132, Article 138132
Main Authors: Zhu, Bicheng, Yu, Luo, Beikzadeh, Sara, Zhang, Shuyuan, Zhang, Peikai, Wang, Li, Travas-Sejdic, Jadranka
Format: Article
Language:English
Subjects:
Ascorbic acid
Diabetes mellitus
Dopamine
Glucose
Glucose detection
Gold
Gold nanoparticles
Graphene
Laser-induced graphene electrode
Lasers
Metabolites
Nanoparticles
Non-enzymatic detection
Nutrition
Oxidation
Selectivity
Sensors
Uric acid
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Summary:Glucose is one of the most important metabolites and a primary nutrient in human body metabolism. Abnormal levels of glucose can cause diabetes mellitus and related complications. Here, we developed a disposable and portable non-enzymatic glucose sensor strip based on gold-nanoparticles (AuNPs)-modified laser-scribed graphene electrode (LSGE). Disposable LSGEs, with a highly porous structure, were fabricated by laser scribing on a commercially available polyimide plastic sheets, followed by electrodepositing of AuNPs, that are electrocatalytic for glucose oxidation. The laser scribing process was optimised in term of laser power, laser speed and pulse per inch (PPI). The effect of number of the electrochemical deposition cycles of AuNPs on LSGE was also investigated and optimised. The sensor provides a linear detection range for the glucose concentrations between 10 µM to 10 mM with a limit of detection of 6.3 µM and shows a good selectivity towards interfering agents, such as urea L-ascorbic acid, uric acid, dopamine, and Na+. The LSGE/AuNP strips have a potential to be used as disposable glucose sensor strips for point-of-care glucose measurements, including self-monitoring and nutrition management.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2021.138132