Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK–STROKE)

Trimethyllysine (TML) is involved in the generation of the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO) by gut microbiota. In clinical studies, elevated TML levels predicted major adverse cardiovascular events (MACE) in patients with acute or stable coronary artery disease (CAD). In cont...

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Bibliographic Details
Published in:Amino acids 2021-04, Vol.53 (4), p.555-561
Main Authors: Schwedhelm, Edzard, von Lucadou, Mirjam, Peine, Sven, Lezius, Susanne, Thomalla, Götz, Böger, Rainer, Gerloff, Christian, Choe, Chi-un
Format: Article
Language:English
Subjects:
Age
Analytical Chemistry
Biochemical Engineering
Biochemistry
Biomarkers
Biomedical and Life Sciences
Cardiovascular disease
Cerebral infarction
Cholesterol
Coronary artery
Coronary artery disease
Creatinine
Fibrillation
Heart attacks
Heart diseases
Hypertension
Intestinal microflora
Ischemia
Life Sciences
Lysine
Metabolites
Microbiota
Myocardial infarction
Neurobiology
Original Article
Post-translational modifications (PTM)
Proteomics
Risk analysis
Risk factors
Sex
Stroke
Trimethylamine
Trimethylamine-N-oxide
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Summary:Trimethyllysine (TML) is involved in the generation of the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO) by gut microbiota. In clinical studies, elevated TML levels predicted major adverse cardiovascular events (MACE) in patients with acute or stable coronary artery disease (CAD). In contrast to cardiovascular patients, the role of TML in patients with acute cerebral ischemia is unknown. Here, we evaluated circulating TML levels in 374 stroke patients from the prospective biomarkers in stroke (MARK–STROKE) study. Compared with 167 matched healthy controls, acute ischemic stroke patients had lower median TML plasma concentrations, i.e. 0.71 vs. 0.47 µmol/L ( p  
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-021-02969-x