Injectable Self‐Healing Hydrogel Wound Dressing with Cysteine‐Specific On‐Demand Dissolution Property Based on Tandem Dynamic Covalent Bonds

Rapid gelation and on‐demand dissolution are key characteristics governing the effectiveness of clinic hydrogel wound dressings. Here, an injectable self‐healing hydrogel with rapid gelation and cysteine‐specific on‐demand dissolution is designed to be used as wound dressings. The hydrogel is prepar...

Full description

Saved in:
Bibliographic Details
Published in:Advanced functional materials 2021-05, Vol.31 (19), p.n/a
Main Authors: Ding, Xiaoya, Li, Gao, Zhang, Peng, Jin, E., Xiao, Chunsheng, Chen, Xuesi
Format: Article
Language:English
Subjects:
Biocompatibility
Bonding
Chemical bonds
Covalence
Covalent bonds
Cysteine
Demand
Dissolution
Gelation
Hydrogels
Injectability
injectable
Materials science
on‐demand dissolutions
self‐healing
wound dressing
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rapid gelation and on‐demand dissolution are key characteristics governing the effectiveness of clinic hydrogel wound dressings. Here, an injectable self‐healing hydrogel with rapid gelation and cysteine‐specific on‐demand dissolution is designed to be used as wound dressings. The hydrogel is prepared based on the formation of tandem dynamic covalent bonds comprised of CC double bonds produced through the catalysis‐free Knoevenagel condensation reaction and boronate ester linkages. The prepared hydrogel displays excellent injectability and self‐healing ability, showing rapid cysteine‐triggered on‐demand dissolution owing to the formation of the thiazolidino boronate complex. When used as dressings for healing full‐thickness wounds, the hydrogel shows favorable biocompatibility, achieves rapid wound closure in seconds, and fast on‐demand dissolution for dressing changes. These data highlight the utility of the designed tandem dynamic covalent bonds‐based hydrogel dressings for promising wound healing applications. An injectable self‐healing hydrogel is prepared through the formation of tandem dynamic covalent bonds comprised of CC double bonds formed by the catalysis‐free Knoevenagel condensation reaction and boronate ester linkages. The obtained hydrogels display rapid gelation and cysteine‐specific on‐demand dissolution behaviors, which could be used as promising wound dressings.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202011230