Platinum complexes act as shielding agents against virus infection

We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechani...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-05, Vol.57 (38), p.4666-4669
Main Authors: Bailly, Benjamin, Gorle, Anil K, Dirr, Larissa, Malde, Alpeshkumar K, Farrell, Nicholas P, Berners-Price, Susan J, von Itzstein, Mark
Format: Article
Language:English
Subjects:
Adducts
Enteroviruses
Glycosaminoglycans
Platinum
Shielding
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Summary:We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development. An interdisciplinary approach determines that TriplatinNC binds to cell-surface heparan sulfate to protect cells from virus infection.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01593a