Protective effect of Lycium barbarum polysaccharide on di-(2-ethylhexyl) phthalate-induced toxicity in rat liver

Di-(2-ethylhexyl)-phthalate (DEHP) is the most commonly used plasticizer and it has been a ubiquitous environmental contaminant which affects health. The purpose of this study was to investigate the protective effect of the Lycium barbarum polysaccharide (LBP) at dosages of 100, 200, and 300 mg/kg b...

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Bibliographic Details
Published in:Environmental science and pollution research international 2021-05, Vol.28 (18), p.23501-23509
Main Authors: Liu, Rui-jing, He, Yong-jian, Liu, Huan, Zheng, Dong-dong, Huang, Shao-wen, Liu, Chun-hong
Format: Article
Language:English
Subjects:
Animal research
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Chemical compounds
Contaminants
Detoxification
Dioctyl phthalate
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Gene expression
Liver
Lycium barbarum
Natural & organic foods
Oxidative stress
Pharmacology
Phthalates
Polysaccharides
Research Article
Toxicity
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Di-(2-ethylhexyl)-phthalate (DEHP) is the most commonly used plasticizer and it has been a ubiquitous environmental contaminant which affects health. The purpose of this study was to investigate the protective effect of the Lycium barbarum polysaccharide (LBP) at dosages of 100, 200, and 300 mg/kg bw on DEHP-induced (3000 mg/kg) toxicity in rat liver through a 28-day animal experiment. The results showed that LBP attenuated oxidative stress slightly by lowering the production of ROS and improving the activity of SOD and GSH-Px in liver and serum of DEHP treatment rats. At the same time, the levels of PXR, CYP450, CYP2E1, CYP3A1, UGT1, and GST were reduced after LBP treatment. Moreover, LBP decreased the mRNA expression of PXR, UGT1, and GST significantly. These findings suggested that LBP might ameliorate DEHP-induced liver injury by down-regulating the expression of PXR in liver, further down-regulating the downstream phase I and II detoxification enzymes, thus reducing the damage caused by DEHP. Therefore, LBP may have the potential to become an auxiliary therapeutic agent as a natural ingredient of health food.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-020-11990-8