Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population

• Published in: Environmental science and pollution research international 2021-05, Vol.28 (18), p.23060-23072
• Main Authors: Flores-Ramírez, Rogelio, Ortega-Romero, Manolo, Christophe-Barbier, Olivier, Meléndez-Marmolejo, Jessica Guadalupe, Rodriguez-Aguilar, Maribel, Lee-Rangel, Héctor A., Díaz de León-Martínez, Lorena
• Format: Article
• Language: English
• Subjects: Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Biomarkers; Biomass burning; Biomedical materials; Burning; Carcinogens; Cardiovascular diseases; Correlation; Creatinine; Damage; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Exposure; Gelatinase; Genotoxicity; Households; Humans; Indigenous peoples; Kidney; Kidneys; Leukocytes (neutrophilic); Lipocalin; Lung diseases; Metabolites; Mexico; Osteopontin; Polycyclic Aromatic Hydrocarbons; Population; Population Groups; Population studies; Research Article; Retinol-binding protein; Smoke; Traditions; Vitamin A; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-021-12388-w

The traditions and habits of indigenous communities in México include the use of wood and biomass burning to cook their food, which generates large amounts of smoke and therefore pollution inside the households. This smoke is composed of a complex mixture of polycyclic aromatic hydrocarbons (PAHs) which at high levels of exposure cause carcinogenic, genotoxic effects and some chronic pulmonary and cardiovascular diseases; however, few studies relate kidney health with exposure to PAHs. Thus, the aim of this study was the evaluation of 10 hydroxylated metabolites of PAHs (OH-PAHs), and their correlation with biomarkers of early kidney damage renal (cystatin-C (Cys-C)), osteopontin (OPN), retinol-binding protein-4 (RPB-4), and neutrophil gelatinase-associated lipocalin (NGAL) in the indigenous population of the Huasteca Potosina in Mexico. The results demonstrate the presence of the OH-PAHs and kidney damage biomarkers in 100% of the study population. The OH-PAHs were shown in the following order of frequency, 1-OH-PYR > 4-OH-PHE > 2-OH-NAP > 1-OH-NAP > 9-OH-FLU > 3-OH-FLU > 2-OH-FLU > 3-OH-PHE and with the following percentages of detection 97.6, 87.8, 78, 73.2, 68.3, 31.7, 14.6, and 12.2%, respectively. NGAL and RBP-4 were present in above 85% of the population, with mean concentrations of 78.5 ± 143.9 and 139.4 ± 131.7 ng/g creatinine, respectively, OPN (64%) with a mean concentration of 642.6 ± 723.3 ng/g g creatinine, and Cys-C with a mean concentration of 33.72 ± 44.96 ng/g creatinine. Correlations were found between 1-OH-NAP, 2-OH-NAP, 9-OH-FLU, and 4-OH-PHE and the four biomarkers of early kidney damage. 3-OH-FLU with OPN and 1-OH-PYR correlated significantly with NGAL, OPN, and RPB-4.