Gene Silencing: Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer (Small 19/2021)

Lipid nanoparticles encapsulating two different small interfering ribonucleic acids are developed that block essential pathways for cancer cell survival. Targeting of metastasized ovarian cancer cells is further enhanced by coating nanoparticles with hyaluronan. Robust gene silencing in key tissues...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-05, Vol.17 (19), p.n/a
Main Authors: Singh, Manu Smriti, Ramishetti, Srinivas, Landesman‐Milo, Dalit, Goldsmith, Meir, Chatterjee, Sushmita, Palakuri, Ramesh, Peer, Dan
Format: Article
Language:English
Subjects:
Cancer
gene delivery
Hyaluronic acid
lipid nanoparticle
Lipids
Nanoparticles
Nanotechnology
Ovarian cancer
Ribonucleic acid
RNA
small interfering RNA
Survival
targeting
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Summary:Lipid nanoparticles encapsulating two different small interfering ribonucleic acids are developed that block essential pathways for cancer cell survival. Targeting of metastasized ovarian cancer cells is further enhanced by coating nanoparticles with hyaluronan. Robust gene silencing in key tissues involved in ovarian cancer pathophysiology in an advanced ovarian cancer mouse model and improved median and overall survival are demonstrated by Dan Peer and co‐workers in article number 2100287.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202170086