Promise of gold nanomaterials as a lung cancer theranostic agent: a systematic review

Lung cancer is considered to be the second most prevalent form of cancer in the world and is associated with high mortality rates. Early diagnosis and targeted therapies for lung cancer can significantly extend patient survival. However, traditional strategies for lung cancer diagnosis lack sensitiv...

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Bibliographic Details
Published in:International nano letters 2021-06, Vol.11 (2), p.93-111
Main Authors: Niloy, Mahruba Sultana, Shakil, Md. Salman, Hossen, Md. Sakib, Alam, Morshed, Rosengren, Rhonda J.
Format: Article
Language:English
Subjects:
Antibodies
Biomedical materials
Biomolecules
Chemistry and Materials Science
Diagnosis
Drugs
Gold
Lung cancer
Materials Science
Medical diagnosis
Nanochemistry
Nanomaterials
Nanoscale Science and Technology
Nanotechnology
Peptides
Photosensitivity
Review
Selectivity
Side effects
Tempering
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Summary:Lung cancer is considered to be the second most prevalent form of cancer in the world and is associated with high mortality rates. Early diagnosis and targeted therapies for lung cancer can significantly extend patient survival. However, traditional strategies for lung cancer diagnosis lack sensitivity and selectivity. Additionally, available conventional drugs are losing their therapeutic potential due to side effects and the development of drug resistance. To overcome these drawbacks, there is an urgency to develop new potent theranostic agents to detect and combat cancer at an early stage. Recently, intensive progress has been made in the development and biomedical application of nanomaterials in cancer diagnosis, detection, and treatment. Gold nanomaterials (GNMs) have drawn considerable attention as a nano-theranostic agent due to their unique and tunable physical features. Therefore, this review aims to systematically analyze the efficiency of GNMs as a lung cancer theranostic agent. Published articles related to the study were selected from three popular electronic online databases including PubMed, Google Scholar, and Web of Science. Studied articles ( n  = 61) demonstrated that GNMs modified with photosensitive agents, miRNA, antibodies, peptides, conventional chemotherapeutic drugs, and other biomolecules improved the efficacy and efficiency of traditional diagnostic and therapeutic strategies to combat lung cancer. Surface-modified GNMs can be used as reliable, accurate, sensitive, and cheap lung cancer detection tools, as well as potent selective cytotoxic agents.
ISSN:2008-9295
2228-5326
DOI:10.1007/s40089-021-00332-2