Progress of Dialkyl Azodicarboxylates in Organic Transformations

In recent past, dialkyl azodicarboxylates have been embraced as versatile reagents in synthetic strategies other than Mitsunobu reactions. These azo compounds have been utilized as an oxidant or dehydrogenating reagent in oxidative transformations, such as cross dehydrogenative coupling, oxidative U...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2021-05, Vol.10 (5), p.964-979
Main Authors: Singh, Pushpinder, Mritunjay
Format: Article
Language:English
Subjects:
Azo compounds
C-Het bond
Dehydrogenation
Dialkyl azodicarboxylates
Organic chemistry
oxidative C−H activation
Oxidizing agents
Photochemical reactions
Reagents
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Summary:In recent past, dialkyl azodicarboxylates have been embraced as versatile reagents in synthetic strategies other than Mitsunobu reactions. These azo compounds have been utilized as an oxidant or dehydrogenating reagent in oxidative transformations, such as cross dehydrogenative coupling, oxidative Ugi‐type reaction, dehydrogenation etc. Moreover, they have been utilized in different types of bond construction like C‐Heteroatom (C‐Het) and S−N bond. Very recently, these azo compounds have also been explored in photochemical reactions. Such types of reported reactions and their reaction pathways are presented here in this minireview, which manifested the oxidative abilities and advantageous features of dialkyl azodicarboxylates. An all‐rounder reagent. A brief summary of recent organic transformations mediated by dialkyl azodicarboxylates, popularly known for Mitsunobu reaction, is given in this minireview. Moreover, synthetic procedures and reaction pathways of these selected reactions are also highlighted.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202100104