Unprecedented reactions for molecular editing

To make the range of molecules that is needed for these applications, chemists are armed with an array of methods that promote specific chemical changes, often with exquisite selectivity. [...]countless chemical-synthesis methods are discovered and published daily. The authors developed a new, easil...

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Bibliographic Details
Published in:Nature (London) 2021-05, Vol.593 (7858), p.203-204
Main Authors: Unsworth, William P, Avestro, Alyssa-Jennifer
Format: Article
Language:English
Subjects:
Carbon
Chemical synthesis
Chemistry
Chemists
Editing
Free radicals
Nitrogen
Reagents
Selectivity
Online Access:Get full text
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Summary:To make the range of molecules that is needed for these applications, chemists are armed with an array of methods that promote specific chemical changes, often with exquisite selectivity. [...]countless chemical-synthesis methods are discovered and published daily. The authors developed a new, easily prepared chemical reagent to promote the reaction, the mechanism of which involves an unprecedented molecular rearrangement: a molecule of nitrogen is lost from a reaction intermediate, producing two highly reactive free radicals that combine to form a new carbon-carbon (C-C) bond (see Fig. 1b of the paper1). A practical advantage to Kennedy and colleagues' synthetic strategy is that it mitigates the costs and safety problems associated with many established C-C bond-forming methods, which usually require expensive or toxic metal reagents.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-021-01205-6