Anti-Inflammatory Potential from Tilapia (Oreochromis niloticus) Viscera Hydrolysate with Bioinformatics Analysis (Prediction of Activity Spectra for Substances – PASS)

• Published in: IOP conference series. Earth and environmental science 2021-05, Vol.750 (1), p.12044
• Main Authors: Riyadi, PH, Romadhon, Anggo, AD, Suharto, S, Tanod, WA, Aryani, A
• Format: Article
• Language: English
• Subjects: Bioinformatics; Biological activity; Bones; Environmental impact; Hydrolysates; Impact analysis; Inflammation; Oreochromis niloticus; Peptides; Ponds; Subtilisin; Tilapia; Viscera
• ISSN: 1755-1307; 1755-1315
• DOI: 10.1088/1755-1315/750/1/012044

Tilapia ( Oreochromis niloticus ) production in Indonesia for 5 (five) years has increased by 18%. Increased production of tilapia ( Oreochromis niloticus ) will result in an increase in fish waste and by-products, such as viscera, skin, bones, and scales. This waste can have an impact on environmental, health, social, and economic problems if not appropriately managed. Hydrolysis technology can turn viscera tilapia waste into more useful hydrolysate. This article aims to obtain a profile of the potential hydrolysates of tilapia viscera as an anti-inflammatory by bioinformatics analysis. The material used in this study was tilapia viscera waste. The waste is then hydrolyzed with alcalase enzyme to produce hydrolysate. LC-HRMS screening shows that there are 99 compounds and eight peptides. PASS analysis is used to predict the potential for biological activity. Most of the total hydrolysate content of tilapia viscera waste has potential biological activity as an anti-inflammatory. These results indicate that tilapia viscera waste hydrolysate has the potential as an anti-inflammatory.