Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5‐Triazinanes with Donor‐Acceptor Aziridines and Their Anti‐Tumor Activity

A Y(OTf)3‐catalyzed [3+2] cycloaddition of 1,3,5‐triazinanes with donor‐acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an SN1‐like pathway. Furthermore, these imidazoli...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2021-05, Vol.363 (10), p.2619-2624
Main Authors: Shi, Zhichao, Fan, Tingting, Zhang, Xun, Zhan, Feng, Wang, Zhe, Zhao, Lei, Lin, Jin‐Shun, Jiang, Yuyang
Format: Article
Language:English
Subjects:
1,3,5-Triazinanes
Anti-tumor activity
Cycloaddition
Donor-acceptor aziridines
Imidazolidines
Substitutes
Tumors
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Summary:A Y(OTf)3‐catalyzed [3+2] cycloaddition of 1,3,5‐triazinanes with donor‐acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an SN1‐like pathway. Furthermore, these imidazolidines exhibit promising anti‐tumor activity against a series of human cancer cell lines.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202001569