Hyaluronic Acid/Polylysine Composites for Local Drug Delivery: A Review

Site specific drug delivery systems (DDS) are usually developed to overcome the side effects of conventional ones (e.g. injections or oral ingestions), creating smart drug delivery vehicles characterized with greater efficiency, safety, predictable therapeutic response as well as controlled and prol...

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Bibliographic Details
Published in:Key Engineering Materials 2020-06, Vol.850, p.213-218
Main Authors: Tračuma, Elīza, Loca, Dagnija
Format: Article
Language:English
Subjects:
Bilayers
Biocompatibility
Central nervous system
Composite materials
Crosslinking
Drug delivery systems
Hyaluronic acid
Hydrogels
Lysine
Multilayers
Side effects
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Summary:Site specific drug delivery systems (DDS) are usually developed to overcome the side effects of conventional ones (e.g. injections or oral ingestions), creating smart drug delivery vehicles characterized with greater efficiency, safety, predictable therapeutic response as well as controlled and prolonged drug release periods. DDS made of hyaluronic acid (HA) and poly-L-lysine (PLL) are promising candidates in the field of local drug delivery due to their high biocompatibility. Moreover, electrostatic attractions between negatively charged HA and positively charged PLL can be used to fabricate multilayer films, bilayer films and hydrogels, avoiding the application of toxic crosslinking agents. In this review, we report the preparation of HA/PLL composites exploiting their intrinsic properties, as well as developed composite application possibilities as controlled drug delivery systems in bone tissue, central nervous system and gene engineering.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.850.213