Is There a Difference in Anxiety, Body Perception, and Depression Scales According to Subphenotypes of Polycystic Ovary Syndrome?

• Published in: Ankara Ueniversitesi Tip Fakültesi mecmuasi 2021-04, Vol.74 (1), p.38-42
• Main Authors: Gökçay Canpolat, Asena, Demir, Özgür, Sert, Merve Sema, Yarsan, Betül, Tekfidan, Züleyha, Yaman, Şeyma Nur, Oğuz, Esmanur, Gazal, Ela, Şimşek, Hande Hatice, Altun Ensari, Tuğba, Çorapçıoğlu, Demet
• Format: Article
• Language: English
• Subjects: Androgens; Anxiety; Body mass index; Cardiovascular disease; Emotional disorders; Genotype & phenotype; Infertility; Insulin resistance; Menstruation; Mental depression; Metabolic syndrome; Mood disorders; Obesity; Ovaries; Polycystic ovary syndrome; Quality of life; Sağlık Hizmetleri; Statistical analysis; Tıp
• ISSN: 1307-5608; 0365-8104; 1307-5608
• DOI: 10.4274/atfm.galenos.2021.52244

Objectives: Polycystic ovary syndrome (PCOS) is the most prevalent female reproductive disorder. PCOS is associated with increased mood disorders. We aimed to evaluate the association between PCOS sub-phenotypes and anxiety, body perception, and depression scales in our study. Materials and Methods: We enrolled 74 patients with PCOS and we assigned them into subphenotypes of PCOS. The Beck depression inventory (BDI-II) was used for depression, the Beck anxiety inventory (BAI) was used for anxiety, and the body esteem scale (BES) was used to assess body perception for all participants. Results: The BDI-II scores of phenotype A were higher than phenotype D. The BAI scores of phenotype A were higher than phenotype B, C, and D. There was no difference between BES scores through all PCOS phenotypes. There was a difference in modified Ferriman-Gallwey score between phenotypes except between phenotype A and phenotype B (p=0.13). An increase in BMI by 1 kg/m2 was found to cause a 0.49 increase in depression scores (p=0.01) but there was no association between BMI and BAI and BES scores (p=0.33, p=0.18). Conclusion: PCOS is associated with mood disorders, especially anxiety and depression. Until now, there was no information about the prevalence of mood disturbances according to subphenotypes of PCOS. The higher prevalence of depression was seen in phenotype A than phenotype D but it was similar among A, B, and C. It has suggested that hyperandrogenism may have a causative effect on pathogenesis of depression in women with PCOS. The higher BAI scores were recorded in phenotype A than phenotype B, C, and D, and BES scores were similar through phenotypes. Although we could not find a close phenotype-mood disorder association, we believe the need for screening for mood disorders, especially anxiety and depression, for patients with PCOS because of the importance of the disease’s psychological consequences.